Question #1

Tell me about the future of immunotherapies and in particular of CAR-T therapies

CAR-T (Chimeric Antigen Receptor T-cell) therapies are a promising type of immunotherapy that have already shown significant success in treating certain types of cancer. In the future, research in this field is expected to continue and focus on improving efficacy, reducing side effects and expanding the types of cancer that can be treated. Additionally, efforts are being made to develop more cost-effective and accessible CAR-T therapies. It is also likely that the use of CAR-T will be combined with other immunotherapies and cancer treatments to enhance overall patient outcomes. However, challenges such as the development of resistance to CAR-T therapy and the need for personalized approaches to treatment will also need to be addressed. Despite these challenges, the future of CAR-T and immunotherapies more broadly, looks promising, and ongoing advancements in this field hold great potential to improve cancer treatments and patient outcomes.

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Tell me about the future of immunotherapies and in particular of CAR-T therapies

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Why are CAR-T therapies so expensive?

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What are you referring to when mentioning the ongoing efforts to reduce the cost of CAR-T therapies?

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Have you heard about rapid manufacturing process to produce faster and cheaper CAR-T therapies?

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4

What about allogeneic strategies? Are allogeneic CAR-T therapies as effective as autologous CAR-T therapies?

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5

What about in vivo CAR-T therapies (also called in situ CAR-T therapies)?

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6

What are the results to date of CAR-T therapies against solid tumors?

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7

Who are the key players (either biotech or pharma companies) developing CAR-T therapies?

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8

What about new comers developing in situ strategies like Umoja, Interius, Sana, Tidal ?

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Alaya.bio is a preclinical-stage biotech developing novel CAR-T therapies. The company has been co-founded by Dr. Cécile BAUCHE and Renaud VAILLANT.

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10

Is it interesting to work for in vivo CAR-T companies like Alaya.bio?

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